Hagiwara Lab, Department of Biochemistry and Applied Chemistry, Kurume National College of Technology

1. Inactivation of the conserved open reading frame ycf34 of Synechocystis sp. PCC 6803 interferes with the photosynthetic electron transport chain,
   Wallner T., Hagiwara Y., Bernat G., Sobotka R., Reijerse J. E., Frankenberg-Dinkel N. and Wilde A.,
   Biochimica et Biophysica Acta - Bioenergetics, in press.


2. Expression, crystallization and X-ray data collection of the cyanobacterial biliverdin reductase,
   Watanabe A., Hirata K., Hagiwara Y., Yutani Y., Sugishima M., Yamamoto M., Fukuyama K. and Wada K.,
   Acta Crystallogr. Sect. F, 67, 313-317 (2011).


3. One residue substitution in PcyA leads to unexpected changes in tetrapyrrole substrate binding,
   Wada K., Hagiwara Y., Yutani Y. and Fukuyama K.,
   Biochem. Biophys. Res. Commun., 402, 373-377 (2010).


4. Structural insights into vinyl reduction regiospecificity of phycocyanobilin:ferredoxin oxidoreductase (PcyA),
   Hagiwara Y., Sugishima M., Khawn H., Kinoshita H., Inomata K., Shang L., Lagarias J. C., Takahashi Y. and Fukuyama K.,
   J. Biol. Chem., 285, 1000-1007 (2010).
   　　-> selected as a "Papers of the Week".
   　　-> selected as a "Must Read", Faculty of 1000.


5. Induced-fitting and electrostatic potential change of PcyA upon substrate binding demonstrated by the crystal structure of the substrate-free form,
   Hagiwara Y., Sugishima M., Takahashi Y. and Fukuyama K.,
   FEBS Letters, 580, 3823-3828 (2006).


6. Crystal structure of phycocyanobilin:ferredoxin oxidoreductase in complex with biliverdin IXα, a key enzyme in the biosynthesis of phycocyanobilin,
   Hagiwara Y.*, Sugishima M.*, Takahashi Y. and Fukuyama K.,
   Proc. Natl. Acad. Sci. U.S.A., 103, 27-32 (2006).
   　　-> selected as "From the Cover".
   　　* These authors contributed equally to this work.


7. Crystal structure of dimeric heme oxygenase-2 from Synechocystis sp. PCC 6803 in complex with heme,
   Sugishima M., Hagiwara Y., Zhang X., Yoshida T., Migita C. T. and Fukuyama K.,
   Biochemistry, 44, 4257-4266 (2005).

1. フェレドキシン依存性ビリン還元酵素の構造研究、
   杉島正一、萩原義徳、高橋康弘、福山恵一、
   日本結晶学会誌、48, 283-289 (2006).

【招待講演】